shock, septic

Craig Mayer, Nick WIlliams, Vojtech Huser
Lister Hill National Center for Biomedical Communications, National Library of Medicine, NIH, Bethesda, MD

See the full regCTG repository at https://github.com/lhncbc/CRI/tree/master/regCTG

To return to the list of conditions and view other reports go to https://lhncbc.github.io/CRI/regCTG/regCTG-condition_report_links.html

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Study Counts

Type	Study_count
Total_Studies	325
interventional	239
Observational	79
Registry	7

Studies over Time by Start Date

```

Interventional Trials

Intervention Type

intervention_type	Study_Count
Drug	101
Other	33
Drug|placebo	31
Device	20
Procedure	12
Biological	10
Device|Other	7
Drug|Other	7
Behavioral	2
Biological|placebo	2
Combination Product	2
Device|Procedure	2
Diagnostic Test	2
Dietary Supplement	2
Biological|Device|Drug	1
Biological|Drug	1
Biological|Other	1
Diagnostic Test|Other	1
Drug|placebo|Procedure	1
Other|Procedure	1

Count of Studies by Intervention (normalized and mapped)

Interventions over Time

Yearly studies for each intervention by start date

Studies by Country

Country	Study_Count
France	40
United States	34
Germany	15
Italy	14
NA	14
China	13
Brazil	11
Thailand	10
Egypt	9
India	8
Canada	6
Denmark	5
Mexico	4
Austria	3
Chile	3
Czechia	3
Spain	3
Greece	2
Indonesia	2
Korea, Republic of	2
Netherlands	2
Sweden	2
Tunisia	2
United States|Canada	2
Australia|Belgium|Canada|Czech Republic|Finland|France|Spain	1
Australia|Brazil|New Zealand	1
Australia|Denmark|New Zealand|Saudi Arabia|United Kingdom	1
Australia|France	1
Austria|Belgium|France|Germany|Israel|Italy|Netherlands|Portugal|United Kingdom	1
Belgium	1
Belgium|Czechia|Denmark|Finland|France|Italy|Netherlands|Norway|Spain|Sweden|Switzerland	1
Belgium|Denmark	1
Belgium|France|Germany|Netherlands	1
Belgium|France|Netherlands	1
Belgium|France|Netherlands|Spain	1
Belgium|France|Spain	1
Denmark|Finland	1
Denmark|Finland|Iceland|Norway	1
Denmark|Finland|Norway|Sweden	1
Finland	1
Finland|Switzerland	1
Japan	1
Jordan	1
Malaysia	1
Qatar	1
Russian Federation	1
Singapore	1
Switzerland	1
Taiwan	1
Turkey	1
United Kingdom	1
United States|Australia|Belgium|Brazil|Canada|Czech Republic|Finland|France|Germany|India|Italy|Mexico|Netherlands|New Zealand|Portugal|Spain|Switzerland|United Kingdom	1
United States|Belgium|Canada|Denmark	1
United States|Brazil|Canada|Greece|India|Pakistan|Philippines	1

Sites per Study

Site_count	Study_Count
1	170
2	16
3	4
4	3
5	2
6	4
7	2
8	2
9	3
10	1
11	1
12	2
13	2
14	1
15	1
16	3
17	1
18	4
26	1
30	2
31	1
32	2
33	1
34	1
35	1
40	1
42	1
48	1
52	2
57	1
70	1
150	1

Phase

Phase	Study_Count
N/A	97
Phase 2	44
Phase 3	43
Phase 4	24
Phase 2/Phase 3	17
Phase 1	7
Phase 1/Phase 2	7

Number of Arms

Number_of_Arms	Count_of_Studies
1	28
2	167
3	17
4	8
5	1
7	3
NA	15

Enrollment Metrics by Phase

Measure	N.A	Phase.1	Phase.1.Phase.2	Phase.2	Phase.2.Phase.3	Phase.3	Phase.4
Min.	8.0000	9.00000	10.00000	7.0000	18	4.0000	9.00
1st Qu.	39.0000	20.00000	12.50000	31.7500	50	91.7500	41.50
Median	80.0000	23.00000	40.00000	51.5000	90	251.0000	85.00
Mean	213.9794	28.14286	87.57143	116.0909	128	452.3571	357.50
3rd Qu.	180.0000	37.50000	94.00000	154.0000	200	587.5000	210.75
Max.	4138.0000	50.00000	350.00000	500.0000	380	1818.0000	3800.00

Trial Group Type

group_type	Group_Count
Experimental	209
Active Comparator	123
Placebo Comparator	65
No Intervention	37
Other	31
NA	15
Sham Comparator	6

Intervention Model

intervention_model	Study_Count
Parallel Assignment	183
Single Group Assignment	38
Crossover Assignment	7
Factorial Assignment	7
Sequential Assignment	2
NA	2

Primary Purpose

primary_purpose	Study_Count
Treatment	198
Diagnostic	11
Other	6
Prevention	6
Basic Science	5
Supportive Care	5
NA	4
Health Services Research	3
Screening	1

Observational Studies

Studies by Country

Country	Study_Count
France	15
United States	15
Germany	7
NA	7
Italy	6
China	2
Czechia	2
Spain	2
Switzerland	2
United Kingdom	2
Argentina	1
Austria|Germany	1
Belgium	1
Belgium|France|Germany|Italy|Netherlands	1
Canada	1
Canada|Sweden	1
Czechia|Italy	1
Denmark	1
Denmark|Finland	1
Egypt	1
Hungary	1
India	1
Lithuania	1
Mexico	1
Singapore	1
Taiwan	1
Thailand	1
United States|Canada	1
United States|Sweden	1

Sites per Study

Site_count	Study_Count
1	60
2	3
3	1
4	1
5	2
7	3
9	2
10	1
12	1
13	1
21	1
24	1
64	1
248	1

Enrollment Metrics

Measure	Observational
Min	10.0000
1st Qu	50.0000
Median	100.0000
Mean	899.2338
3rd Qu	305.0000
Max	50000.0000

Observation Model

observational_model	Study_Count
Cohort	54
Case-Only	16
Case-Control	5
NA	2
Defined Population	1
Other	1

Time Perspective

time_perspective	Study_Count
Prospective	66
Retrospective	10
Cross-Sectional, Prospective	1
Other	1
NA	1

Registries

Studies by Country

Country	Study_Count
France	3
Czechia	1
Germany	1
India	1
Thailand	1

Sites per Study

Site_count	Study_Count
1	6
6	1

Enrollment Metrics

Measure	Registries
Min	50.000
1st Qu	140.000
Median	458.000
Mean	1826.857
3rd Qu	3000.000
Max	6000.000

Registry Model

observational_model	Study_Count
Cohort	6
Case-Control	1

Time Perspective

time_perspective	Study_Count
Prospective	6
Cross-Sectional	1

Follow-up

target_duration	Study_Count
90 Days	2
1 Day	1
1 Month	1
3 Months	1
6 Months	1
7 Days	1

Overview of Studies

Interventional Trials

#If less then 500 trials

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT04459572	As an Early Indicator Biomarker of Prognosis and Mortality in Children With Sepsis and Septic Shock: suPAR	https://ClinicalTrials.gov/show/NCT04459572	Completed	Ege University	2019-09-27
NCT02079402	Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care	https://ClinicalTrials.gov/show/NCT02079402	Completed	Scandinavian Critical Care Trials Group	2015-11-30
NCT03818269	Study of Subcutaneous Interstitial Pressure During Sepsis	https://ClinicalTrials.gov/show/NCT03818269	Recruiting	Centre Hospitalier Universitaire Dijon	2021-11-30
NCT03677102	Fluids in Septic Shock (FISSH)	https://ClinicalTrials.gov/show/NCT03677102	Recruiting	McMaster University	2021-07-01
NCT03380507	Evaluation of Hydrocortisone, Vitamin C and Thiamine for the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT03380507	Recruiting	Hamad Medical Corporation	2019-04-30
NCT03378466	Heparin Anticoagulation in Septic Shock	https://ClinicalTrials.gov/show/NCT03378466	Recruiting	University of Manitoba	2020-12-31
NCT03366220	Resuscitation With Plasma in Surgical and Trauma Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03366220	Enrolling by invitation	The University of Texas Health Science Center, Houston	2021-03-26
NCT03343041	Study of Low Carbohydrate Enteral Nutrition in Patients With Bacterial Septic Shock	https://ClinicalTrials.gov/show/NCT03343041	Recruiting	Yale University	2022-01-31
NCT03340805	Pragmatic Pediatric Trial of Balanced Versus Normal Saline Fluid in Sepsis: A Pilot Feasibility Study	https://ClinicalTrials.gov/show/NCT03340805	Completed	Children’s Hospital of Philadelphia	2018-08-31
NCT03338569	Vitamin C and Septic Shock	https://ClinicalTrials.gov/show/NCT03338569	Recruiting	University of Minnesota	2020-06-20
NCT03333278	The Vitamin C, Hydrocortisone and Thiamine in Patients With Septic Shock Trial	https://ClinicalTrials.gov/show/NCT03333278	Completed	Australian and New Zealand Intensive Care Research Centre	2019-07-16
NCT03292120	Venous to Arterial Carbon Dioxide Difference (P₍ᵥ₋ₐ₎CO₂): Predictor of Septic Patient Prognosis Depending on the ScvO₂	https://ClinicalTrials.gov/show/NCT03292120	Completed	Assistance Publique Hopitaux De Marseille	2018-11-30
NCT03258684	Hydrocortisone, Vitamin C, and Thiamine for the Treatment of Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT03258684	Completed	Zhujiang Hospital	2019-02-02
NCT03251170	Ketamine Versus Fentanyl for Induction of Anesthesia in Septic Shock	https://ClinicalTrials.gov/show/NCT03251170	Completed	Cairo University	2019-12-25
NCT03246893	Efficacy of HFNC Versus NIV for Prevent Reintubation in Sepsis Patients	https://ClinicalTrials.gov/show/NCT03246893	Recruiting	Mahidol University	2020-04-30
NCT03208257	Esmolol to Control Adrenergic Storm in Septic Shock- ROLL-IN 2	https://ClinicalTrials.gov/show/NCT03208257	Recruiting	Intermountain Health Care, Inc.	2020-12-31
NCT03201575	REmote Ischemic COnditioning in Septic Shock	https://ClinicalTrials.gov/show/NCT03201575	Active, not recruiting	Hospices Civils de Lyon	2019-08-31
NCT03193164	Neuromuscular Electrical Stimulation and Septic Shock	https://ClinicalTrials.gov/show/NCT03193164	Recruiting	University of Sao Paulo	2019-07-01
NCT03158948	Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of 3 Doses of MOTREM in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03158948	Completed	Inotrem	2018-06-13
NCT03137446	Restrictive Intravenous Fluids Trial in Sepsis	https://ClinicalTrials.gov/show/NCT03137446	Completed	Rhode Island Hospital	2018-03-30
NCT03120637	Evaluating in Cirrhotics With Refractory Vasoplegia the Effect of Methylene Blue	https://ClinicalTrials.gov/show/NCT03120637	Completed	Institute of Liver and Biliary Sciences, India	2018-01-10
NCT03104140	Ketamine Versus Low Dose Thiopental for Induction of Anesthesia in Septic Shock	https://ClinicalTrials.gov/show/NCT03104140	Completed	Cairo University	2018-04-01
NCT03092245	Vasculopathic Injury and Plasma as Endothelial Rescue in Septic Shock (SHOCK) Trial	https://ClinicalTrials.gov/show/NCT03092245	Active, not recruiting	Rigshospitalet, Denmark	2020-04-01
NCT03085758	Treatment of Patients With Early Septic Shock and Bio-Adrenomedullin(ADM) Concentration > 70 pg/ml With ADRECIZUMAB	https://ClinicalTrials.gov/show/NCT03085758	Completed	Adrenomed AG	2019-12-20
NCT03078712	Early Goal Directed Therapy Using a Physiological Holistic View. The ANDROMEDA-SHOCK Study	https://ClinicalTrials.gov/show/NCT03078712	Completed	Pontificia Universidad Catolica de Chile	2018-03-15
NCT03065751	Plasmaexchange in Early Septic Shock	https://ClinicalTrials.gov/show/NCT03065751	Recruiting	Hannover Medical School	2021-01-31
NCT03038503	What Should be the Next Vasopressor for Severe Septic Shock? Methylene Blue or Terlipressin	https://ClinicalTrials.gov/show/NCT03038503	Recruiting	Ramathibodi Hospital	2018-12-31
NCT03029169	Propafenone Versus Amiodarone in Septic Shock	https://ClinicalTrials.gov/show/NCT03029169	Recruiting	Charles University, Czech Republic	2021-06-30
NCT03013322	Anticholium® Per Se	https://ClinicalTrials.gov/show/NCT03013322	Completed	University Hospital Heidelberg	2017-02-18
NCT02972827	Monitoring Devices in Prediction of Fluid Responsiveness in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02972827	Recruiting	Santa Barbara Cottage Hospital	2020-05-31
NCT02971670	Amendment of rTSST-1 Variant Vaccine Phase 1 Clinical Trial	https://ClinicalTrials.gov/show/NCT02971670	Completed	Biomedizinische Forschungs gmbH	2016-03-31
NCT02937961	Early Versus Late Sustained Low Efficiency Dialysis in Critically Ill Cirrhotics With Septic Shock and Acute Kidney Injury	https://ClinicalTrials.gov/show/NCT02937961	Recruiting	Institute of Liver and Biliary Sciences, India	2019-03-01
NCT02885168	Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C	https://ClinicalTrials.gov/show/NCT02885168	Completed	Central Hospital, Nancy, France	2009-04-30
NCT02841241	Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia	https://ClinicalTrials.gov/show/NCT02841241	Completed	Intermountain Health Care, Inc.	2017-03-31
NCT02835157	Balanced Salt Solutions vs. Normal Saline in Children With Septic Shock	https://ClinicalTrials.gov/show/NCT02835157	Completed	All India Institute of Medical Sciences, New Delhi	2019-10-15
NCT02820987	PK/PD of Extended-infusion Meropenem, Piperacillin-tazobactam and Cefepime in the Early Phase of Septic Shock	https://ClinicalTrials.gov/show/NCT02820987	Recruiting	Centre Hospitalier Universitaire de Besancon	2016-09-01
NCT02820675	Quality Improvement in Infection COntrol and Sepsis Management in MOdel Regions	https://ClinicalTrials.gov/show/NCT02820675	Recruiting	Center for Sepsis Control and Care, Germany	2019-07-31
NCT02805049	Pharmacokinetic Study on Echinocandins for Patients With Septic Shock Following Secondary Peritonitis	https://ClinicalTrials.gov/show/NCT02805049	Completed	Centre Hospitalier Universitaire de NÄ«mes	2018-06-23
NCT02768740	Hydrocortisone 50 mg Every 6 Hours Compared to Hydrocortisone 300 mg Per Day in Treatment of Septic Shock.	https://ClinicalTrials.gov/show/NCT02768740	Completed	Association Niçoise de Réanimation Médicale	2010-05-31
NCT02748382	Fluids in Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02748382	Completed	McMaster University	2017-08-19
NCT02734550	(1,3)-β-D-glucan Based Diagnosis of Invasive Candida Infection in Sepsis	https://ClinicalTrials.gov/show/NCT02734550	Completed	Center for Sepsis Control and Care, Germany	2019-08-22
NCT02730624	Piperacillin/Tazobactam in Critically Ill Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02730624	Completed	Prince of Songkla University	2016-05-31
NCT02681653	Study the Impact of Statins in Septic Shock	https://ClinicalTrials.gov/show/NCT02681653	Completed	Sanjay Gandhi Postgraduate Institute of Medical Sciences	2014-10-31
NCT02664753	L-carnitine as an Adjunct Treatment for Septic Shock Patients With Acute Kidney Injury	https://ClinicalTrials.gov/show/NCT02664753	Recruiting	Centre Hospitalier Universitaire de NÄ«mes	2021-03-31
NCT02655133	Effects on Microcirculation of IgGAM in Severe Septic/Septic Shock Patients.	https://ClinicalTrials.gov/show/NCT02655133	Completed	Università Politecnica delle Marche	2018-01-01
NCT02647554	Ulinastatin Treatment in Adult Patients With Sepsis and Septic Shock in China	https://ClinicalTrials.gov/show/NCT02647554	Recruiting	Peking Union Medical College Hospital	2020-05-31
NCT02638779	REAnimation Low Immune Status Markers	https://ClinicalTrials.gov/show/NCT02638779	Completed	Hospices Civils de Lyon	2018-06-27
NCT02638545	Hemodynamic Effects of Dexmedetomidine in Septic Shock	https://ClinicalTrials.gov/show/NCT02638545	Completed	University of Roma La Sapienza	2017-01-31
NCT02635854	Study of Platelet Activation in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT02635854	Completed	University Hospital, Toulouse	2017-01-31
NCT02600312	Comparing Cytokines, Toxins Adsorbing oXiris Filter to ST150 Filter During CRRT in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02600312	Completed	Skane University Hospital	2018-01-31
NCT02814708	Clinical Trial of the BioMed rTSST‐1 Variant Vaccine in Healthy Adults	https://ClinicalTrials.gov/show/NCT02814708	Active, not recruiting	Biomedizinische Forschungs gmbH	2020-09-30
NCT02566460	The Effect of Lactate Clearance Oriented Haemodynamic Therapy on the Outcome of Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02566460	Completed	Peking Union Medical College Hospital	2014-12-31
NCT03389555	Ascorbic Acid, Corticosteroids, and Thiamine in Sepsis (ACTS) Trial	https://ClinicalTrials.gov/show/NCT03389555	Recruiting	Beth Israel Deaconess Medical Center	2019-12-30
NCT02519699	Microcirculation After MAP Increase in Septic Shock Patients With Previous Hypertension	https://ClinicalTrials.gov/show/NCT02519699	Completed	Federal University of São Paulo	2016-11-30
NCT02473718	Fluid Balance in the ICU - Interventions to Minimize Fluids in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02473718	Completed	Washington University School of Medicine	2014-12-31
NCT02473263	Samu Save Sepsis: Early Goal Directed Therapy in Pre Hospital Care of Patients With Severe Sepsis and/or Septic Shock	https://ClinicalTrials.gov/show/NCT02473263	Active, not recruiting	Assistance Publique - Hôpitaux de Paris	2019-02-09
NCT02468063	To Assess the Efficacy of Early Introduction of a Combination of Low Dose Vasopressin Analogue in Addition to Noradrenaline as a Vasopressor in Patients of Cirrhosis With Septic Shock	https://ClinicalTrials.gov/show/NCT02468063	Completed	Institute of Liver and Biliary Sciences, India	2017-05-31
NCT02453425	The Effects of Blood Pressure on Renal Function and Oxygenation in Septic Shock	https://ClinicalTrials.gov/show/NCT02453425	Completed	Sahlgrenska University Hospital, Sweden	2017-03-31
NCT02427048	Clinical Practice Guidelines and Impact of Audit and Feedback in the Emergency Department	https://ClinicalTrials.gov/show/NCT02427048	Completed	Denver Health and Hospital Authority	2016-04-30
NCT02421484	Cellular Immunotherapy for Septic Shock: A Phase I Trial	https://ClinicalTrials.gov/show/NCT02421484	Completed	Ottawa Hospital Research Institute	2016-06-30
NCT02369900	Esmolol to Treat the Hemodynamic Effects of Septic Shock	https://ClinicalTrials.gov/show/NCT02369900	Completed	Beth Israel Deaconess Medical Center	2019-12-31
NCT02361528	GM-CSF to Decrease ICU Acquired Infections	https://ClinicalTrials.gov/show/NCT02361528	Completed	Hospices Civils de Lyon	2018-06-01
NCT02354742	Echo vs. EGDT in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02354742	Completed	Intermountain Health Care, Inc.	2017-05-31
NCT02340338	rTSST-1 Variant Vaccine Phase 1 First-in-man Trail	https://ClinicalTrials.gov/show/NCT02340338	Completed	Biomedizinische Forschungs gmbH	2015-06-30
NCT02336620	Balanced Salt Solution VS. Normal Saline Solution in Septic Shock	https://ClinicalTrials.gov/show/NCT02336620	Completed	Ramathibodi Hospital	2017-01-30
NCT02270281	Dexmedetomidine on Microcirculation in Septic Shock	https://ClinicalTrials.gov/show/NCT02270281	Completed	Southeast University, China	2016-12-31
NCT02266589	Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02266589	Completed	Nanjing PLA General Hospital	2013-10-31
NCT02246595	Studying Complement Inhibition in Early, Newly Developing Septic Organ Dysfunction	https://ClinicalTrials.gov/show/NCT02246595	Completed	InflaRx GmbH	2015-12-31
NCT02213796	Population Pharmacokinetics and Monte Carlo Dosing Simulations of Meropenem During the Early Phase of Severe Sepsis and Septic Shock in Critically Ill Patients in Intensive Care Units	https://ClinicalTrials.gov/show/NCT02213796	Completed	Prince of Songkla University	2013-12-31
NCT02204852	Co-administration of Iloprost and Eptifibatide in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT02204852	Completed	Rigshospitalet, Denmark	2016-08-31
NCT02135770	Impact of Low Dose Unfractionated Heparin Treatment on Inflammation in Sepsis	https://ClinicalTrials.gov/show/NCT02135770	Completed	Indonesia University	2014-06-30
NCT02120404	Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT02120404	Recruiting	Assistance Publique - Hôpitaux de Paris	2020-09-30
NCT02114710	Effects of Stress Doses of Hydrocortisone on Coagulation Dysfunction in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02114710	Completed	Nanjing PLA General Hospital	2012-10-31
NCT02085291	Effect of Different Strategies for Titrating a High MAP on Microcirculation	https://ClinicalTrials.gov/show/NCT02085291	Completed	Southeast University, China	2016-09-30
NCT02062970	Interest of the Balance of Pro-coagulating and Profibrinolytis Activities of the Microparticles (MP) in the Prognosis of Septic Shock	https://ClinicalTrials.gov/show/NCT02062970	Active, not recruiting	Assistance Publique Hopitaux De Marseille	2018-01-31
NCT01310790	Strategy of Early Improvement of Tissue Oxygenation Decrease the Mortality of Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT01310790	Completed	Chinese Septic Shock Network	2009-10-31
NCT01284452	Efficacy of Hydrocortisone in Treatment of Severe Sepsis/Septic Shock Patients With Acute Lung Injury/Acute Respiratory Distress Syndrome (ARDS)	https://ClinicalTrials.gov/show/NCT01284452	Completed	Mahidol University	2014-12-31
NCT01271153	Effects of Dobutamine on Microcirculation, Regional and Peripheral Perfusion in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT01271153	Completed	Pontificia Universidad Catolica de Chile	2013-01-31
NCT02053675	Hemodynamic Effects of Vasopressin in Early Septic Shock Stage	https://ClinicalTrials.gov/show/NCT02053675	Completed	Federal University of São Paulo	2013-04-30
NCT02050893	The Effect of Midazolam on Fluid Responsiveness in Septic Patients	https://ClinicalTrials.gov/show/NCT02050893	Completed	Southeast University, China	2013-04-30
NCT01988428	Prehospital Antibiotics Against Sepsis Trial	https://ClinicalTrials.gov/show/NCT01988428	Completed	VU University Medical Center	2017-06-30
NCT01973907	Pilot Study for the SQUEEZE Trial	https://ClinicalTrials.gov/show/NCT01973907	Completed	McMaster Children’s Hospital	2016-06-30
NCT01972828	Early Haemodynamic Optimization Using Preload Dependence During Septic Shock = EHOSS-1	https://ClinicalTrials.gov/show/NCT01972828	Completed	Hospices Civils de Lyon	2013-08-31
NCT01948778	The Effects of a Polyethyleneimine-coated Membrane (oXirisâ„¢) for Hemofiltration Versus Polymyxin B- Immobilized Fibre Column (Toraymyxinâ„¢) for Hemoperfusion on Endotoxin Activity and Inflammatory Conditions in Septic Shock- A Randomized Controlled Pilot Study (ENDoX-study)	https://ClinicalTrials.gov/show/NCT01948778	Completed	University of Zurich	2019-05-31
NCT01945983	Early Use of Norepinephrine in Septic Shock Resuscitation	https://ClinicalTrials.gov/show/NCT01945983	Completed	Mahidol University	2017-08-31
NCT01845766	Effects of Early Exercise Rehabilitation on Long-term Functional Recovery in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT01845766	Completed	Yonsei University	2014-11-30
NCT02025660	Efficacy of Mw Vaccine in Treatment of Severe Sepsis	https://ClinicalTrials.gov/show/NCT02025660	Completed	Postgraduate Institute of Medical Education and Research	2014-02-28
NCT01827007	Assessment of Fluid Responsiveness by Elevation of PEEP in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT01827007	Completed	Helsinki University Central Hospital	2012-12-31
NCT01790620	Impact of CVVHD With Adsorption Capacity Membranes in Septic Acute Kidney Injury	https://ClinicalTrials.gov/show/NCT01790620	Completed	Hospital Universitari de Bellvitge	2017-08-31
NCT01784159	ASpirin for Patients With SEPsis and SeptIc Shock	https://ClinicalTrials.gov/show/NCT01784159	Recruiting	Federal University of São Paulo	2020-12-31
NCT02025127	A Randomized Controlled Study of Enteral Nutrition in Septic Shock	https://ClinicalTrials.gov/show/NCT02025127	Completed	Medical College of Wisconsin	2018-01-31
NCT01718613	Vasopressin Versus Norepinephrine for the Management of Septic Shock in Cancer Patients	https://ClinicalTrials.gov/show/NCT01718613	Completed	Instituto do Cancer do Estado de São Paulo	2014-03-31
NCT01665092	Rapid Administration of Carnitine in sEpsis	https://ClinicalTrials.gov/show/NCT01665092	Completed	University of Mississippi Medical Center	2018-03-31
NCT01649921	The Effects of Interferon-gamma on Sepsis-induced Immunoparalysis	https://ClinicalTrials.gov/show/NCT01649921	Completed	Radboud University	2016-12-31
NCT01648036	Heparin Anticoagulation to Improve Outcomes in Septic Shock: The HALO Pilot	https://ClinicalTrials.gov/show/NCT01648036	Completed	University of Manitoba	2014-01-31
NCT01612676	Investigating FE 202158 as Potential Primary Treatment in Patients With Early Septic Shock	https://ClinicalTrials.gov/show/NCT01612676	Completed	Ferring Pharmaceuticals	2013-11-30
NCT01611753	Red Blood Cell Transfusion Improves Perfusion Parameters in Septic Shock Patients With Hypoperfusion	https://ClinicalTrials.gov/show/NCT01611753	Completed	Federal University of São Paulo	2008-08-31
NCT01585909	Evaluation of Intestinal Brush Border Enzyme Function in Critically Ill Patients	https://ClinicalTrials.gov/show/NCT01585909	Completed	Medical University of Vienna	2015-02-28
NCT01526382	Use of PiCCO System in Critically Ill Patients With Septic Shock and Acute Respiratory Distress Syndrome	https://ClinicalTrials.gov/show/NCT01526382	Completed	Jinhua Central Hospital	2014-06-30
NCT01517815	Pharmacokinetic of Doripenem and Piperacillin/Tazobactam in More Than 120 kg Critically Ill Patients	https://ClinicalTrials.gov/show/NCT01517815	Completed	University Hospital, Montpellier	2013-06-30
NCT01485315	Transfusion-requirements in Septic Shock Trial	https://ClinicalTrials.gov/show/NCT01485315	Completed	Scandinavian Critical Care Trials Group	2014-03-31
NCT01473498	Personalized Mean Arterial Pressure Management on Renal Function During Septic Shock	https://ClinicalTrials.gov/show/NCT01473498	Completed	Assistance Publique - Hôpitaux de Paris	2015-10-31
NCT01453270	Emergency Department Management of Sepsis Patients: A Goal-Oriented Non-Invasive Sepsis Trial	https://ClinicalTrials.gov/show/NCT01453270	Completed	National University Hospital, Singapore	2014-03-31
NCT01448109	ADjunctive coRticosteroid trEatment iN criticAlly ilL Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT01448109	Completed	The George Institute	2017-10-22
NCT01443494	High MAP in Septic Shock With Hypertension	https://ClinicalTrials.gov/show/NCT01443494	Completed	Southeast University, China	2012-06-30
NCT01411670	Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock.	https://ClinicalTrials.gov/show/NCT01411670	Completed	University of Roma La Sapienza	2015-02-28
NCT01393782	Intravenous AII for the Treatment of Severe Hypotension in High Output Shock: A Pilot Study	https://ClinicalTrials.gov/show/NCT01393782	Completed	George Washington University	2014-01-31
NCT01352182	Pharmacokinetic and Biomarker Study of Pioglitazone in Adolescents With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT01352182	Completed	Children’s Hospital Medical Center, Cincinnati	2016-05-31
NCT01337934	Lactated Ringer Versus Albumin in Early Sepsis Therapy	https://ClinicalTrials.gov/show/NCT01337934	Completed	University of Sao Paulo	2016-10-31
NCT04446871	Methylene Blue in Early Septic Shock	https://ClinicalTrials.gov/show/NCT04446871	Recruiting	Hospital Civil de Guadalajara	2020-09-30
NCT04398069	Hemodynamic Optimisation Guided With Transcranial Doppler in Septic Shock	https://ClinicalTrials.gov/show/NCT04398069	Recruiting	Mongi Slim Hospital	2020-08-31
NCT04302584	Norepinephrine / Vasopressin Combination for Resuscitation in Septic Shock	https://ClinicalTrials.gov/show/NCT04302584	Completed	Ain Shams University	2019-01-05
NCT04281277	Relation Between Mean Arterial Pressure and Renal Resistive Index in the Early Phase of Septic Shock	https://ClinicalTrials.gov/show/NCT04281277	Recruiting	University Hospital, Angers	2025-01-15
NCT04259567	Improvement of Cerebrovascular Autoregulation in Patients With Septic Shock Due to Cytokine Elimination	https://ClinicalTrials.gov/show/NCT04259567	Recruiting	Johannes Gutenberg University Mainz	2021-12-31
NCT04257136	VBI-S for the Treatment of Hypotension in Hypovolemic Septic Shock Patients	https://ClinicalTrials.gov/show/NCT04257136	Recruiting	Vivacelle Bio	2020-12-31
NCT04231994	Therapeutic Plasmaexchange in Early Septic Shock	https://ClinicalTrials.gov/show/NCT04231994	Recruiting	Hannover Medical School	2020-06-01
NCT04227652	Control of Fever in Septic Patients	https://ClinicalTrials.gov/show/NCT04227652	Completed	University Hospital Ostrava	2019-02-28
NCT04197115	Vitamin C, Thiamine, Cyanocobalamine, Pyridoxine and Hydrocortisone in Sepsis	https://ClinicalTrials.gov/show/NCT04197115	Recruiting	IMSS Hospital General de Zona 11, Piedras Negras	2020-08-30
NCT04178148	Personalized Dose Optimization of Amikacin Guided by Pharmacokinetic Modeling Software in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT04178148	Recruiting	Centre Hospitalier Universitaire de NÄ«mes	2020-05-31
NCT04156451	Effect of Fluid Deresuscitation With Central Venous Pressure Target 0-4 mmHg in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT04156451	Recruiting	Indonesia University	2020-06-30
NCT04152174	Safety and Efficiency of Combined Extracorporeal Blood Purification in Neurosurgical ICU. Prospective RCT	https://ClinicalTrials.gov/show/NCT04152174	Recruiting	Burdenko Neurosurgery Institute	2021-04-10
NCT04134624	EMS Prehospital Blood Culture Collection and Antibiotic Administration: A Two-Phase Pilot Project to Reduce Mortality in Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04134624	Enrolling by invitation	HealthPartners Institute	2021-01-31
NCT04130230	Adjuvant Use of Neostigmine in Sepsis and Septic Shock.	https://ClinicalTrials.gov/show/NCT04130230	Recruiting	Mansoura University	2020-03-31
NCT04123444	Infusion of Prostacyclin (Iloprost) vs Placebo for 72-hours in Patients With Septic Shock Suffering From Organ Failure	https://ClinicalTrials.gov/show/NCT04123444	Recruiting	Rigshospitalet, Denmark	2022-09-30
NCT04111822	Pilot Study on the Use of Hydrocortisone, Vitamin c and Tiamine in Patient With Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04111822	Recruiting	Institut d’Investigació Biomèdica de Girona Dr. Josep Trueta	2020-10-31
NCT04107402	PLatelets Acetyl-CoA Carboxylase Phosphorylation State in SEPtic Shock	https://ClinicalTrials.gov/show/NCT04107402	Recruiting	Cliniques universitaires Saint-Luc- Université Catholique de Louvain	2021-03-15
NCT04089072	Methylene Blue as a Third-line Vasopressor in Septic Shock	https://ClinicalTrials.gov/show/NCT04089072	Recruiting	Carilion Clinic	2021-10-01
NCT04055909	Efficacy, Safety and Tolerability of Nangibotide in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT04055909	Recruiting	Inotrem	2021-04-30
NCT04013269	Adjuvant Therapy With CytoSorb in Refractory Septic Shock	https://ClinicalTrials.gov/show/NCT04013269	Recruiting	Universitätsklinikum Hamburg-Eppendorf	2021-12-31
NCT03989609	Dexmedetomidine in Modifying Immune Paralysis In Patient With Septic Shock	https://ClinicalTrials.gov/show/NCT03989609	Recruiting	Kasr El Aini Hospital	2020-02-20
NCT03974386	Effects of Endotoxin Absorption and Cytokine Removal Hemofilter on Severe Septic Shock	https://ClinicalTrials.gov/show/NCT03974386	Recruiting	National Taiwan University Hospital	2020-09-30
NCT03961594	Evaluation of New Hemodynamic Indices	https://ClinicalTrials.gov/show/NCT03961594	Recruiting	Assistance Publique Hopitaux De Marseille	2018-09-01
NCT03953677	Evaluation of the Effect of Dexmedetomidine on Phenylephrine Response During Refractory Septic Shock	https://ClinicalTrials.gov/show/NCT03953677	Recruiting	Centre Hospitalier Universitaire Dijon	2021-04-30
NCT03924518	Adjunctive Granisetron Therapy in Patients With Sepsis or Septic Shock	https://ClinicalTrials.gov/show/NCT03924518	Recruiting	Zhujiang Hospital	2020-12-31
NCT03920982	Prognostic Value Serum Concentration of Indoxyl Sulfate During Acute Kidney Injury in Septic Shock Patients.	https://ClinicalTrials.gov/show/NCT03920982	Recruiting	Centre Hospitalier Universitaire, Amiens	2022-04-30
NCT03901807	Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Endotoxemic Septic Shock in a Randomized, Open-Label Study	https://ClinicalTrials.gov/show/NCT03901807	Recruiting	Spectral Diagnostics (US) Inc.	2021-10-31
NCT03898674	Microcirculatory Guided Goal Directed Fluid Therapy in Septic Shock; a Feasibility Study	https://ClinicalTrials.gov/show/NCT03898674	Recruiting	King’s College London	2020-10-01
NCT03891342	Effect of Fluid Challenge on Glycocalyx	https://ClinicalTrials.gov/show/NCT03891342	Completed	University Hospital Hradec Kralove	2018-07-31
NCT03869385	Albumin Replacement Therapy in Septic Shock	https://ClinicalTrials.gov/show/NCT03869385	Recruiting	Jena University Hospital	2021-07-21
NCT03866083	Safety and Efficacy of Extracorporeal Cytokine Hemoadsorption in Septic Shock in Critically Ill Cirrhotics	https://ClinicalTrials.gov/show/NCT03866083	Recruiting	Institute of Liver and Biliary Sciences, India	2019-06-30
NCT03844984	Lidocaine-Ketamine Versus Ketamine for Induction of Anesthesia in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03844984	Completed	Cairo University	2019-09-20
NCT03837171	TRANSfusion in Patients With Onco-hematological Malignancies ResusciTated From Septic Shock	https://ClinicalTrials.gov/show/NCT03837171	Recruiting	Assistance Publique - Hôpitaux de Paris	2021-02-20
NCT03835286	Vitamin C to Reduce Vasopressor Dose in Septic Shock	https://ClinicalTrials.gov/show/NCT03835286	Recruiting	Hospital Español de Mexico	2020-04-30
NCT03788837	Ilomedin in Septic Shock With Persistent Microperfusion Defects (I-MICRO)	https://ClinicalTrials.gov/show/NCT03788837	Recruiting	Assistance Publique - Hôpitaux de Paris	2022-08-03
NCT03783091	A Trial of Vitamin B12 in Septic Shock	https://ClinicalTrials.gov/show/NCT03783091	Recruiting	Medical College of Wisconsin	2023-12-31
NCT03765489	Electrical Muscle Stimulation in the Development of Acquired Weakness in Patients With Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT03765489	Completed	University of Chile	2018-06-21
NCT03762005	Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock	https://ClinicalTrials.gov/show/NCT03762005	Recruiting	Pontificia Universidad Catolica de Chile	2019-09-30
NCT03756220	Ascorbic Acid and Thiamine Effect in Septic Shock	https://ClinicalTrials.gov/show/NCT03756220	Recruiting	Samsung Medical Center	2019-11-30
NCT03754257	Effects of High-frequency Electrical Stimulation for Preventing Loss of Muscle Mass in Patients With Sepsis	https://ClinicalTrials.gov/show/NCT03754257	Recruiting	Hospital Sirio-Libanes	2021-04-01
NCT03748537	Mitochondrial Function in Septic Patients	https://ClinicalTrials.gov/show/NCT03748537	Completed	Chiang Mai University	2019-12-31
NCT03710187	HCT+F vs. HCT Alone in Critically Ill Medical Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03710187	Completed	University of Tennessee Medical Center	2019-09-27
NCT03706053	Midodrine Use in Septic Shock	https://ClinicalTrials.gov/show/NCT03706053	Recruiting	University of Virginia	2020-03-31
NCT03700346	Muscle Lactate and Lactate to Pyruvate Ratio Clearance in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03700346	Recruiting	Military Hospital of Tunis	2018-10-30
NCT03683329	Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock	https://ClinicalTrials.gov/show/NCT03683329	Recruiting	Institut Paoli-Calmettes	2020-11-30
NCT03668236	The Conservative vs. Liberal Approach to Fluid Therapy of Septic Shock in Intensive Care Trial	https://ClinicalTrials.gov/show/NCT03668236	Recruiting	Scandinavian Critical Care Trials Group	2020-11-30
NCT03661268	The Effect of Rapid Fluid Challenge Under Pulmonary Artery Catheter Monitoring on Physiological Indexes of Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03661268	Recruiting	Chengdu Fifth People’s Hospital	2019-09-30
NCT03654001	ALBumin Italian Outcome Septic Shock-BALANCED Trial (ALBIOSS-BALANCED)	https://ClinicalTrials.gov/show/NCT03654001	Recruiting	Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico	2020-12-31
NCT03649633	Vitamin C, Steroids, and Thiamine, and Cerebral Autoregulation and Functional Outcome in Septic Shock	https://ClinicalTrials.gov/show/NCT03649633	Recruiting	University of Athens	2020-07-31
NCT03649009	Thiamine As An Adjuvant Therapy For Hyperlactatemia In Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03649009	Recruiting	Universiti Kebangsaan Malaysia Medical Centre	2018-12-01
NCT03608514	Terlipressin Alone Versus the Standard Therapy With Catecholamines for Hepatic Patients With Septic Shock- Prospective Single Center Randomized Controlled Study.	https://ClinicalTrials.gov/show/NCT03608514	Recruiting	National Hepatology & Tropical Medicine Research Institute	2020-07-31
NCT03592693	Vitamin C, Hydrocortisone and Thiamine for Septic Shock	https://ClinicalTrials.gov/show/NCT03592693	Recruiting	University of Athens	2020-07-31
NCT03592277	Vitamin C & Thiamine in Sepsis	https://ClinicalTrials.gov/show/NCT03592277	Recruiting	Saint Francis Care	2020-06-01
NCT03589378	Therapeutic Plasma Exchange Adsorption Diafiltration	https://ClinicalTrials.gov/show/NCT03589378	Recruiting	Shenzhen Second People’s Hospital	2019-12-31
NCT03582046	Targeting Abdominal Perfusion Pressure in Septic Shock	https://ClinicalTrials.gov/show/NCT03582046	Recruiting	Potrero Medical	2021-09-30
NCT03557229	Clinical Trial of Antioxidant Therapy in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03557229	Recruiting	American British Cowdray Medical Center	2020-06-30
NCT03530046	High Strong Ion Difference Fluid vs Hartmann’s Solution on Acid-Base Status in Sepsis	https://ClinicalTrials.gov/show/NCT03530046	Completed	Clinical Research Centre, Malaysia	2017-12-18
NCT03528213	Utility of Sodium Lactate Infusion During Septic Shock	https://ClinicalTrials.gov/show/NCT03528213	Recruiting	University Hospital, Lille	2021-11-30
NCT03461900	Guided Fluid-balance Optimization With Mini-fluid chALlenge During Septic Shock	https://ClinicalTrials.gov/show/NCT03461900	Recruiting	University Hospital, Brest	2023-01-31
NCT03452865	Esomeprazole to Reduce Organ Failure in Sepsis	https://ClinicalTrials.gov/show/NCT03452865	Recruiting	Università Vita-Salute San Raffaele	2022-03-31
NCT01263977	Thermodilution - Controlled Management of Volume Therapy in Septic Shock	https://ClinicalTrials.gov/show/NCT01263977	Completed	Charite University, Berlin, Germany	2014-05-31
NCT01231698	Heart Rate Control With Esmolol in Septic Shock	https://ClinicalTrials.gov/show/NCT01231698	Completed	University of Roma La Sapienza	2012-07-31
NCT01222663	Effects of Hemoperfusion With a Polymyxin B Membrane in Peritonitis With Septic Shock	https://ClinicalTrials.gov/show/NCT01222663	Completed	Meditor SAS	2013-04-30
NCT01188993	Transpulmonary Thermodilution and Transesophageal Echocardiography in Early Septic Shock	https://ClinicalTrials.gov/show/NCT01188993	Completed	University Hospital, Limoges	2014-01-31
NCT01187134	Medical Education for Sepsis Source Control and Antibiotics	https://ClinicalTrials.gov/show/NCT01187134	Completed	Center for Sepsis Control and Care, Germany	2013-06-30
NCT01149278	Assessment of Two Levels of Arterial Pressure on Survival in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT01149278	Completed	University Hospital, Angers	2012-09-30
NCT01144624	A Study to Assess Safety,and Tolerability of 2 Doses of AZD9773 (CytoFabâ„¢) in Japanese With Severe Sepsis/Septic Shock	https://ClinicalTrials.gov/show/NCT01144624	Completed	AstraZeneca	2011-08-31
NCT01071343	Transcutaneous Electric Muscle Stimulation (TEMS) in Septic Patients	https://ClinicalTrials.gov/show/NCT01071343	Completed	Rigshospitalet, Denmark	2009-04-30
NCT01070810	Thiamine as a Metabolic Resuscitator in Septic Shock	https://ClinicalTrials.gov/show/NCT01070810	Completed	Beth Israel Deaconess Medical Center	2014-11-30
NCT01067313	Continuous Hemodialysis With an Enhanced Middle Molecule Clearance Membrane	https://ClinicalTrials.gov/show/NCT01067313	Completed	Fresenius Medical Care France	2010-07-31
NCT01046669	Safety and Efficacy of Polymyxin B Hemoperfusion (PMX) for Septic Shock	https://ClinicalTrials.gov/show/NCT01046669	Completed	Spectral Diagnostics (US) Inc.	2016-07-31
NCT01013662	Lipid Profile in Patients With Severe Sepsis or Septic Shock Under Strict or Liberal Glycemic Control	https://ClinicalTrials.gov/show/NCT01013662	Completed	University of Sao Paulo	2007-07-31
NCT01000649	Effects of the V1a Agonist FE 202158 in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT01000649	Completed	Ferring Pharmaceuticals	2011-08-31
NCT00995839	Terlipressin in Septic Shock: Effects on Microcirculation	https://ClinicalTrials.gov/show/NCT00995839	Completed	University of Roma La Sapienza	2010-02-28
NCT00974935	Phase I STEBVax in Healthy Adults	https://ClinicalTrials.gov/show/NCT00974935	Completed	National Institute of Allergy and Infectious Diseases (NIAID)	2015-03-31
NCT00962156	Scandinavian Starch for Severe Sepsis/Septic Shock Trial	https://ClinicalTrials.gov/show/NCT00962156	Completed	Scandinavian Critical Care Trials Group	2012-03-31
NCT00934011	Use of Inflammatory Biomarkers to Guide Antibiotic Therapy in Patients With Severe Infections	https://ClinicalTrials.gov/show/NCT00934011	Completed	Federal University of Minas Gerais	2012-05-31
NCT00930085	Evaluation of Predictive Proteic Profile on Mortality in the Acute Phase of Septic Shock in Cancer Patients	https://ClinicalTrials.gov/show/NCT00930085	Completed	Institut Paoli-Calmettes	2011-04-30
NCT00922870	Evaluation of Hemodynamic Effects of Cascade Hemofiltration in Septic Shock	https://ClinicalTrials.gov/show/NCT00922870	Completed	Baxter Healthcare Corporation	2013-03-31
NCT04203524	Procalcitonin and Antimicrobial Utilization in Critically Ill Cancer Patients With Sepsis	https://ClinicalTrials.gov/show/NCT04203524	Recruiting	King Hussein Cancer Center	2021-08-21
NCT03911817	Impact of Midodrine Administration on the Clinical Outcome of Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03911817	Completed	Ain Shams University	2019-06-30
NCT03457038	Use of Fc-MBL to Detect and Monitor the Presence of PAMPs During Septic Shock	https://ClinicalTrials.gov/show/NCT03457038	Recruiting	University Hospital, Toulouse	2019-07-18
NCT00832039	Placebo Controlled Trial of Sodium Selenite and Procalcitonin Guided Antimicrobial Therapy in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00832039	Completed	Kompetenznetz Sepsis	2013-03-31
NCT00823108	Rapid Administration of Insulin in Sepsis	https://ClinicalTrials.gov/show/NCT00823108	Completed	Atrium Health	2010-10-31
NCT03401398	Stress Hydrocortisone In Pediatric Septic Shock	https://ClinicalTrials.gov/show/NCT03401398	Recruiting	Seattle Children’s Hospital	2023-09-20
NCT03344627	Clinical Outcome Study of High-dose Meropenem in Sepsis and Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03344627	Completed	Mahidol University	2018-11-30
NCT04339868	Terlipressin for Refractory Septic Shock	https://ClinicalTrials.gov/show/NCT04339868	Recruiting	Mahidol University	2025-03-31
NCT03872011	Vitamin C, Thiamine and Hydrocortisone for the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT03872011	Recruiting	Northern Jiangsu Province People’s Hospital	2020-07-01
NCT02856191	Study on the Frequency of de Novo Atrial Fibrillation in Septic Shock in Medical Intensive Care	https://ClinicalTrials.gov/show/NCT02856191	Completed	Centre Hospitalier Universitaire Dijon	2011-09-30
NCT02580240	Initiation of Hydrocortisone for the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT02580240	Completed	Northern Jiangsu Province People’s Hospital	2016-09-30
NCT02579525	Targeted Tissue Perfusion Versus Macrocirculatory-guided Standard Care in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT02579525	Recruiting	Helsinki University Central Hospital	2020-12-31
NCT01836224	Efficacy and Safety of Monotherapy With Noradrenaline and Terlipressin in Patients of Cirrhosis With Septic Shock Admitted to Intensive Care Unit	https://ClinicalTrials.gov/show/NCT01836224	Completed	Institute of Liver and Biliary Sciences, India	2014-09-30
NCT04110418	Methylene Blue Versus Vasopressin Analogue for Treatment of Septic Shock in Preterm Neonate	https://ClinicalTrials.gov/show/NCT04110418	Recruiting	Ain Shams University	2020-02-19
NCT00763906	Norepinephrine Weaning in Septic Patients	https://ClinicalTrials.gov/show/NCT00763906	Completed	Association pour le Développement de la Recherche et de l’Enseignement en Médecine d’Urgence	2006-11-30
NCT00707122	Volume Replacement With Albumin in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00707122	Completed	Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico	2013-04-30
NCT00676897	Statin Therapy in the Treatment of Sepsis	https://ClinicalTrials.gov/show/NCT00676897	Completed	Beth Israel Deaconess Medical Center	2010-12-31
NCT00639015	Phenylephrine in Septic Shock	https://ClinicalTrials.gov/show/NCT00639015	Completed	University of Roma La Sapienza	2008-06-30
NCT00629382	Early Use of Polymyxin B Hemoperfusion in Abdominal Sepsis	https://ClinicalTrials.gov/show/NCT00629382	Completed	St. Bortolo Hospital	2008-04-30
NCT00628160	Terlipressin in Septic Shock in Cirrhosis	https://ClinicalTrials.gov/show/NCT00628160	Completed	Hospital Clinic of Barcelona	2012-12-31
NCT00625209	Activated Protein C and Corticosteroids for Human Septic Shock	https://ClinicalTrials.gov/show/NCT00625209	Completed	University of Versailles	2015-06-30
NCT00604214	Efficacy and Safety of Drotrecogin Alfa (Activated) in Adult Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT00604214	Completed	Eli Lilly and Company	2011-09-30
NCT00604019	Dopamine Versus Norepinephrine for the Treatment of Vasopressor Dependent Septic Shock	https://ClinicalTrials.gov/show/NCT00604019	Completed	Rush University Medical Center	2009-08-31
NCT00800306	Effects of Levosimendan on Microcirculation in Septic Shock	https://ClinicalTrials.gov/show/NCT00800306	Completed	University of Roma La Sapienza	2008-02-29
NCT00592488	Acetyl-L-Carnitine in the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT00592488	Completed	Vanderbilt University Medical Center	2009-08-31
NCT00534287	Comparison of Two Antibiotic Regimen (Meropenem Versus Meropenem+Moxifloxacin)in the Treatment of Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00534287	Completed	Kompetenznetz Sepsis	2010-04-30
NCT00527007	External Cooling in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT00527007	Completed	Assistance Publique - Hôpitaux de Paris	2010-03-31
NCT00510835	Protocolized Care for Early Septic Shock	https://ClinicalTrials.gov/show/NCT00510835	Completed	University of Pittsburgh	2013-07-31
NCT01145560	A Study to Compare the Efficacy and Safety of 2 Dosing Regimens of IV Infusions of AZD9773 (CytoFabâ„¢) With Placebo in Adult Patients With Severe Sepsis and/or Septic Shock	https://ClinicalTrials.gov/show/NCT01145560	Completed	AstraZeneca	2012-05-31
NCT00481572	Continuous Infusion of Terlipressin in Septic Shock	https://ClinicalTrials.gov/show/NCT00481572	Completed	University of Roma La Sapienza	2007-12-31
NCT00481442	Phenylephrine Versus Norepinephrine in Septic Shock	https://ClinicalTrials.gov/show/NCT00481442	Completed	University of Roma La Sapienza	NA
NCT00407823	Comparison of Pediatric Septic Shock Treatment With and Without Central Venous Oxygen Saturation Monitoring	https://ClinicalTrials.gov/show/NCT00407823	Completed	University of Sao Paulo	NA
NCT00406198	Impact of Continuous Venovenous Haemofiltration on Organ Failure During the Early Phase of Severe Sepsis	https://ClinicalTrials.gov/show/NCT00406198	Completed	Hopital Lariboisière	NA
NCT00329680	The Effects of Eicosapentaenoic Acid (EPA), Gamma-Linolenic Acid (GLA) and Antioxidants in the Treatment of Sepsis	https://ClinicalTrials.gov/show/NCT00329680	Completed	Fernandes Tavora Hospital	2008-12-31
NCT00327704	Early Albumin Resuscitation During Septic Shock	https://ClinicalTrials.gov/show/NCT00327704	Completed	Laboratoire français de Fractionnement et de Biotechnologies	2010-06-30
NCT00320099	Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock	https://ClinicalTrials.gov/show/NCT00320099	Completed	University of Versailles	2009-01-31
NCT00279214	Hemodynamic and Perfusion Response to Drotrecogin Alfa (Activated) in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT00279214	Completed	Eli Lilly and Company	NA
NCT00269685	Comparison of Vasopressin and Other Pressors in Septic Shock	https://ClinicalTrials.gov/show/NCT00269685	Completed	Université de Sherbrooke	NA
NCT00241228	Haemofiltration Study : IVOIRE (hIgh VOlume in Intensive Care)	https://ClinicalTrials.gov/show/NCT00241228	Completed	University Hospital, Bordeaux	2010-10-31
NCT00207844	Selenium, as Sodium Selenite, in the Treatment of Septic Shock	https://ClinicalTrials.gov/show/NCT00207844	Completed	Centre Hospitalier de Meaux	NA
NCT00197886	Dose of Norepinephrine and the Concentration of L-Lactate in the Rectum and Stomach in Patients With Septic Shock.	https://ClinicalTrials.gov/show/NCT00197886	Completed	Herlev Hospital	NA
NCT00159952	Effect of Hyperglycemia in PAI-1 Activity and the Relationship With Outcome in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00159952	Completed	Policlinico Hospital	2007-03-31
NCT00148278	Norepinephrine Plus Dobutamine Versus Epinephrine Alone for the Management of Septic Shock	https://ClinicalTrials.gov/show/NCT00148278	Completed	University of Versailles	2004-12-31
NCT00147004	Corticosteroid Therapy of Septic Shock - Corticus	https://ClinicalTrials.gov/show/NCT00147004	Completed	Hadassah Medical Organization	2005-11-30
NCT00135473	Efficacy of Volume Substitution and Insulin Therapy in Severe Sepsis (VISEP Trial)	https://ClinicalTrials.gov/show/NCT00135473	Completed	SepNet - Critical Care Trials Group	NA
NCT00134212	Dopexamine and Norepinephrine Compared With Epinephrine Alone in Septic Shock	https://ClinicalTrials.gov/show/NCT00134212	Completed	Rennes University Hospital	NA
NCT00819416	Fluid Resuscitation in Early Septic Shock	https://ClinicalTrials.gov/show/NCT00819416	Completed	Ottawa Hospital Research Institute	2009-10-31
NCT00818597	Extracorporeal Immune Support System (EISS) for the Treatment of Septic Patients	https://ClinicalTrials.gov/show/NCT00818597	Completed	University of Rostock	2004-04-30
NCT00046072	A Safety and Efficacy Study of Intravenous E5564 in Patients With Severe Sepsis	https://ClinicalTrials.gov/show/NCT00046072	Completed	Eisai Inc.	NA
NCT00005890	Diagnostic Study of Adrenal Cortical Function in Children With Septic Shock	https://ClinicalTrials.gov/show/NCT00005890	Completed	National Center for Research Resources (NCRR)	NA
NCT00000574	Ibuprofen in Sepsis Study	https://ClinicalTrials.gov/show/NCT00000574	Completed	Vanderbilt University	NA

Observational Studiess

#If less then 500 studies

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03356249	Next-Generation Sequencing Diagnostics of Bacteremia in Sepsis	https://ClinicalTrials.gov/show/NCT03356249	Recruiting	University Hospital Heidelberg	2020-12-31
NCT03136081	Candida Host Defense Response After Septic Shock in the Critically Ill	https://ClinicalTrials.gov/show/NCT03136081	Completed	University Hospital, Montpellier	2015-05-31
NCT03104933	Proadrenomedullin and Copeptin in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03104933	Recruiting	Spanish Network for Research in Infectious Diseases	2019-09-30
NCT03085459	Effects of Nursing Staff on Empiric Antibiotic in Septic Shock	https://ClinicalTrials.gov/show/NCT03085459	Completed	Southeast University, China	2016-02-29
NCT03055455	Neuroimaging and Neuromonitoring in Critically Ill Children With Sepsis	https://ClinicalTrials.gov/show/NCT03055455	Active, not recruiting	Children’s Hospital of Philadelphia	2020-12-31
NCT03014063	Vasopressin Plasma Concentrations in Patients Receiving Exogenous Vasopressin Infusion for Septic Shock	https://ClinicalTrials.gov/show/NCT03014063	Completed	The Cleveland Clinic	2017-06-30
NCT02934997	The Role of Dysfunctional HDL in Sepsis	https://ClinicalTrials.gov/show/NCT02934997	Completed	University of Florida	2019-05-03
NCT02918214	Prognostic Assessment of Diastolic and Systolic Left Ventricular Function in Septic Shock	https://ClinicalTrials.gov/show/NCT02918214	Completed	University Hospital, Limoges	2019-10-31
NCT02887274	Application of Stimulated Immune Response Change to Predict Outcome of Patient With Severe Sepsis	https://ClinicalTrials.gov/show/NCT02887274	Recruiting	Chang Gung Memorial Hospital	2018-12-31
NCT02884011	Evaluating the Effect of Chronic Antihypertensive Therapy on Vasopressor Dosing in Septic Shock	https://ClinicalTrials.gov/show/NCT02884011	Completed	Rush University Medical Center	2017-02-28
NCT02876341	Effects of Chronic Antihypertensive Therapy on Clinical Outcomes in Septic Shock	https://ClinicalTrials.gov/show/NCT02876341	Completed	Rush University Medical Center	2017-02-28
NCT02782013	Study of Progression of Community Acquired Pneumonia in the Hospital	https://ClinicalTrials.gov/show/NCT02782013	Recruiting	Pneumonia Research Network on Genetic Resistance and Susceptibility for the Evolution of Severe Seps	2019-12-31
NCT02780466	Observational Study on Intubation in Septic Shock	https://ClinicalTrials.gov/show/NCT02780466	Completed	University Hospital, Angers	2017-10-31
NCT02750683	Norepinephrine Exerts an Inotropic Effect at the Early Phase of Human Septic Shock	https://ClinicalTrials.gov/show/NCT02750683	Completed	Hopital Antoine Beclere	2016-01-31
NCT02750163	Circulating Free Hemoglobin and Microcirculation After Administration of Paracetamol in Febrile Septic Patient	https://ClinicalTrials.gov/show/NCT02750163	Completed	Università Politecnica delle Marche	2019-06-05
NCT02676427	Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination	https://ClinicalTrials.gov/show/NCT02676427	Recruiting	Charles University, Czech Republic	2021-05-31
NCT02464371	Interest of Plasma microRNAs	https://ClinicalTrials.gov/show/NCT02464371	Completed	Centre Hospitalier Universitaire de Saint Etienne	2017-05-03
NCT02430142	Microcirculatory Oxygen Uptake in Sepsis	https://ClinicalTrials.gov/show/NCT02430142	Completed	Universitätsmedizin Mannheim	2016-10-31
NCT02393781	Adrenomedullin and Outcome in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02393781	Completed	Sphingotec GmbH	2016-05-31
NCT02353910	VTE Incidence in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT02353910	Completed	University of Utah	2014-12-31
NCT02306928	PK Analysis of Piperacillin in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT02306928	Completed	University of Aarhus	2015-01-31
NCT02288975	Adsorbtion of Cytokines Early in Septic Shock: the ACESS Study	https://ClinicalTrials.gov/show/NCT02288975	Completed	Szeged University	2017-12-31
NCT02186522	Immune Failure in Critical Therapy (INFECT) Study	https://ClinicalTrials.gov/show/NCT02186522	Completed	University of Edinburgh	2016-01-31
NCT02174081	ARDS Prediction Score in Critically Ill Patients in China	https://ClinicalTrials.gov/show/NCT02174081	Completed	Southeast University, China	2016-03-31
NCT02135796	Echocardiography in Septic Shock	https://ClinicalTrials.gov/show/NCT02135796	Recruiting	Intermountain Health Care, Inc.	2019-12-31
NCT02116413	Does the Time Between the End of Vascular Filling and Evaluation of Its Effectiveness Modify Fluid Challenge Results in Septic Shock?	https://ClinicalTrials.gov/show/NCT02116413	Completed	Centre Hospitalier Universitaire de NÄ«mes	2016-01-31
NCT02044575	Clock Genes in Patients With Refractory Septic Shock (SeptiClock) - Pilot Study	https://ClinicalTrials.gov/show/NCT02044575	Completed	Charite University, Berlin, Germany	2018-01-21
NCT01943747	International Multicentre Prevalence Study on Sepsis	https://ClinicalTrials.gov/show/NCT01943747	Completed	European Society of Intensive Care Medicine	2013-11-30
NCT01867905	Antibiotic Administration and Blood Culture Positivity in Severe Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT01867905	Completed	University of British Columbia	2018-09-05
NCT01836302	Septic Shock and Delirium Because of rSO2 Abnormalities in Intensive Care Unit Patients (The SAD BRAIN Study)	https://ClinicalTrials.gov/show/NCT01836302	Completed	University of Manitoba	2013-12-31
NCT01668329	Bio-clinical Evolutive Dynamic in Patients Suffering From Communitary Septic Shock (Biosepsis)	https://ClinicalTrials.gov/show/NCT01668329	Completed	University Hospital, Grenoble	2012-10-31
NCT01632059	Examination of ADMA Serum Level and DDAH II	https://ClinicalTrials.gov/show/NCT01632059	Completed	Universitätsklinikum Hamburg-Eppendorf	2013-03-31
NCT01600989	Mitochondrial Function of Immune Cells in Sepsis	https://ClinicalTrials.gov/show/NCT01600989	Completed	University Hospital Inselspital, Berne	2013-10-31
NCT01604551	Membrane Shedding During Septic Shock	https://ClinicalTrials.gov/show/NCT01604551	Completed	University Hospital, Strasbourg, France	NA
NCT01523717	Procalcitonin Monitoring Sepsis Study	https://ClinicalTrials.gov/show/NCT01523717	Completed	Brahms AG	2014-03-31
NCT01392508	IMproved PREdiction of Severe Sepsis in the Emergency Department	https://ClinicalTrials.gov/show/NCT01392508	Completed	Axis Shield Diagnostics Ltd	2015-09-30
NCT01378169	SIRS and Bacterial Sepsis Discrimination by Biomarkers in ICU	https://ClinicalTrials.gov/show/NCT01378169	Completed	Groupe Hospitalier Paris Saint Joseph	2013-01-01
NCT01363635	Severe Sepsis/Septic Shock on Admission to the General Surgical ICU	https://ClinicalTrials.gov/show/NCT01363635	Completed	Mahidol University	2019-01-31
NCT01332734	Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis	https://ClinicalTrials.gov/show/NCT01332734	Completed	Medical Centre Leeuwarden	2010-08-31
NCT01319630	The Effect of Three Different Fluids(Albumin 5%, Normal Saline, Hydroxyethyl Starch 130 kD) on Microcirculation in Severe Sepsis/Septic Shock Patients	https://ClinicalTrials.gov/show/NCT01319630	Completed	Mercy Research	2013-12-31
NCT04388267	Fluid REsponsiveness and Arterial ELASTANCE in Patients With Septic Shock or After Aortic Surgery	https://ClinicalTrials.gov/show/NCT04388267	Recruiting	Central Hospital, Nancy, France	2020-06-30
NCT04231695	Extracorporeal Cytokine Removal in Patients With Septic Shock in an Adult Intensive Care Unit	https://ClinicalTrials.gov/show/NCT04231695	Recruiting	Hospital Jose Maria Cullen	2020-12-31
NCT04153578	Time to Lose the Weight? Comparison of Weight-based and Non-weight-based Vasopressors for Septic Shock	https://ClinicalTrials.gov/show/NCT04153578	Recruiting	Methodist Health System	2020-11-30
NCT04143035	Hemodynamic Resuscitation and Monitoring in Early Sepsis	https://ClinicalTrials.gov/show/NCT04143035	Recruiting	Tata Memorial Centre	2019-12-14
NCT04141410	Global Longitudinal Strain Assessment in Cardiogenic Shock During Sepsis	https://ClinicalTrials.gov/show/NCT04141410	Recruiting	Azienda USL Toscana Centro	2020-10-21
NCT04079829	Postoperative Respiratory Abnormalities	https://ClinicalTrials.gov/show/NCT04079829	Active, not recruiting	Efficacy Care R&D Ltd	2020-10-31
NCT04073771	A Multiple Centre, Cohort Study of New CRRT Membranes oXiris for Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT04073771	Recruiting	Southeast University, China	2020-06-30
NCT04067674	Septic Shock-induced Immunosuppression	https://ClinicalTrials.gov/show/NCT04067674	Recruiting	Hospices Civils de Lyon	2024-11-21
NCT03987048	Cirrhotic Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03987048	Completed	Hospices Civils de Lyon	2015-04-30
NCT03977688	Evaluating a CytoSorb Score in Septic Shock	https://ClinicalTrials.gov/show/NCT03977688	Completed	Klinikum Emden	2019-05-30
NCT03966664	Determination of the Dissociation Constant (Ka) of Plasma and Whole Blood in Septic Patients	https://ClinicalTrials.gov/show/NCT03966664	Recruiting	Fondazione IRCCS Ca’ Granda, Ospedale Maggiore Policlinico	2021-06-30
NCT03933722	Caretaker vs. Blood Pressure Monitoring With Invasive Arterial Pressure Monitoring in Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT03933722	Recruiting	The Cooper Health System	2020-02-04
NCT03931967	Proadrenomedullin and Microcirculation in Monitoring Organ Dysfunction in Patient With Infection	https://ClinicalTrials.gov/show/NCT03931967	Completed	Università Politecnica delle Marche	2019-06-04
NCT03913468	Outcomes of Septic Shock Patients Treated With a Metabolic Resuscitation Bundle Consisting of Intravenous Hydrocortisone, Ascorbic Acid and Thiamine.	https://ClinicalTrials.gov/show/NCT03913468	Active, not recruiting	University of Wisconsin, Madison	2021-01-01
NCT03884595	Early Identification of Sepsis in Children	https://ClinicalTrials.gov/show/NCT03884595	Recruiting	Brno University Hospital	2021-12-31
NCT03847493	Analysis of Sublingual Glycocalyx Damage at ICU Admission to Predict Risk of Death	https://ClinicalTrials.gov/show/NCT03847493	Recruiting	University Hospital Muenster	2020-06-30
NCT03805321	The Validity of Peripheral Perfusion Index to Predict Fluid Responsiveness	https://ClinicalTrials.gov/show/NCT03805321	Recruiting	Cairo University	2019-04-25
NCT03802500	Neurophysiological Diagnosis for ICU Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03802500	Recruiting	Centre Hospitalier Universitaire Vaudois	2019-10-31
NCT03716310	Platelet Reactivity in Septic Shock	https://ClinicalTrials.gov/show/NCT03716310	Completed	Università degli Studi di Ferrara	2018-05-30
NCT03713307	Macro and Micro Haemodynamic Responses to Shock in the Renal and Systemic - MICROSHOCK - RENAL	https://ClinicalTrials.gov/show/NCT03713307	Recruiting	King’s College London	2020-06-30
NCT03663192	Strain Echocardiography During Septic Shock : an Observational Pilot Study	https://ClinicalTrials.gov/show/NCT03663192	Completed	Centre Hospitalier Universitaire de NÄ«mes	2018-03-30
NCT03617965	Mortality Due to Septic Shock Associated With Thrombocytopenia	https://ClinicalTrials.gov/show/NCT03617965	Active, not recruiting	Universidad de Guanajuato	2019-11-15
NCT03472079	TIMP2*IGFBP7 and Transient AKI	https://ClinicalTrials.gov/show/NCT03472079	Recruiting	Centre Hospitalier Universitaire, Amiens	2019-07-01
NCT03456180	Changes in Microvascular Perfusion During Blood Purification With Cytosorb® in Septic Shock	https://ClinicalTrials.gov/show/NCT03456180	Completed	Università Politecnica delle Marche	2017-12-15
NCT03438097	Survey of Non-resuscitation Fluids in Septic Shock	https://ClinicalTrials.gov/show/NCT03438097	Completed	Region Skane	2018-07-30
NCT01231672	Prospective Validation of Clini-biological Parameters Including Initial Hemostasis, Which Improve the Prediction of Death at 1 Month Among Patients With Septic Shock	https://ClinicalTrials.gov/show/NCT01231672	Completed	Centre Hospitalier Universitaire de NÄ«mes	2013-10-31
NCT01062685	Near Infrared Spectroscopy (St02)	https://ClinicalTrials.gov/show/NCT01062685	Completed	Beth Israel Deaconess Medical Center	2010-01-31
NCT02188888	Echocardiographic and Arterial Pressure Waveform Changes After Reducing Heart Rate With Esmolol in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT02188888	Completed	University of Roma La Sapienza	2014-06-30
NCT00811629	Influence of Acute Respiratory Distress Syndrome (ARDS) and Severe Sepsis on sRAGE Levels in ICU Patients	https://ClinicalTrials.gov/show/NCT00811629	Completed	University Hospital, Clermont-Ferrand	2009-07-31
NCT01806428	Activated Protein C and Microcirculation	https://ClinicalTrials.gov/show/NCT01806428	Completed	Università Politecnica delle Marche	2010-12-31
NCT03817996	Fluid Responsiveness in HFNC Patients	https://ClinicalTrials.gov/show/NCT03817996	Completed	Hospital Universitari Vall d’Hebron Research Institute	2019-03-30
NCT00793442	Endothelium in Severe Sepsis	https://ClinicalTrials.gov/show/NCT00793442	Completed	Beth Israel Deaconess Medical Center	2013-05-31
NCT00698048	Serial Vasopressin and Copeptin Levels in Children With Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT00698048	Completed	KK Women’s and Children’s Hospital	2011-12-31
NCT00684736	Tryptophan, Serotonin and Kynurenine in Septic Shock	https://ClinicalTrials.gov/show/NCT00684736	Completed	Versailles Hospital	2007-04-30
NCT00525369	IL 6 Measurement Using a New Densitometric Bedside (POC) Test	https://ClinicalTrials.gov/show/NCT00525369	Completed	Charite University, Berlin, Germany	NA
NCT00523198	Correlation Salivary Cortisol and Free Serum Cortisol to Total Serum Cortisol in MICU Septic Shock	https://ClinicalTrials.gov/show/NCT00523198	Completed	The University of Texas Health Science Center, Houston	2008-08-31
NCT00398736	A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.	https://ClinicalTrials.gov/show/NCT00398736	Completed	Charite University, Berlin, Germany	NA
NCT00197938	Lactic Acid in the Rectum and Life-Threatening Infection	https://ClinicalTrials.gov/show/NCT00197938	Completed	Herlev Hospital	NA
NCT00118664	Patient Plasma Response and Outcome in Septic Shock With Thrombocytopenia Associated Multiple Organ Failure in Children	https://ClinicalTrials.gov/show/NCT00118664	Completed	Children’s Healthcare of Atlanta	2012-02-29

Registries

#If less then 500 registries

nct_id	brief_title	link	overall_status	source	primary_completion_date
NCT03280992	Community Acquired Sepsis Cohort	https://ClinicalTrials.gov/show/NCT03280992	Recruiting	Rennes University Hospital	2019-12-31
NCT03831022	Usefulness of Capillary Refill Time and Skin Mottling Score to Predict Intensive Care Unit Admission	https://ClinicalTrials.gov/show/NCT03831022	Recruiting	Hôpital Necker-Enfants Malades	2020-12-17
NCT03578835	Bloodstream Infection Due to Multidrug-Resistant Organisms - Multicenter Study on Determinants of Clinical Outcomes	https://ClinicalTrials.gov/show/NCT03578835	Recruiting	University Hospital Tuebingen	2018-12-31
NCT03475667	Comparison of Radial and Femoral Artery Site Invasive Blood Pressure Measurement in Septic Shock Patients	https://ClinicalTrials.gov/show/NCT03475667	Completed	Sanjay Gandhi Postgraduate Institute of Medical Sciences	2020-01-10
NCT03861325	Acute Intestinal Failure in Critically Ill Patients and Microbial Translocation	https://ClinicalTrials.gov/show/NCT03861325	Recruiting	Centre Hospitalier Universitaire de NÄ«mes	2020-04-30
NCT04448951	Immune Homeostasis in Sepsis and Septic Shock	https://ClinicalTrials.gov/show/NCT04448951	Recruiting	Charles University, Czech Republic	2021-12-31
NCT01947127	Venous Lactate in Progression to Overt Septic Shock and Mortality in Non-elderly Sepsis Patients in Emergency Department	https://ClinicalTrials.gov/show/NCT01947127	Completed	Chulalongkorn University	2014-11-30